Blake earned a bachelor's degree in electrical engineering from Rice University. He followed it with a year researching and building real-time navigation software for surgical procedures at the M.E.Mueller Institute in Bern, Switzerland. In 2005, he co-founded an e-commerce company, BuildASign.com, which currently employs over 350 in Austin and brought in over $80 million in revenue in 2015. After moving to an advisory role in the business, Blake completed a Ph.D. in bioinformatics at UT Austin in the Marcotte Lab, using machine learning to exploit new experimental techniques in rapidly mapping protein complexes. He loves sunshine, mountains and snow.